5-Fluorouracil and thymine form a crystalline solid solution
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چکیده
منابع مشابه
Solvent effects on the steady-state absorption and fluorescence spectra of uracil, thymine and 5-fluorouracil.
We report a comparison of the steady-state absorption and fluorescence spectra of three representative uracil derivatives (uracil, thymine and 5-fluorouracil) in alcoholic solutions. The present results are compared with those from our previous experimental and computational studies of the same compounds in water and acetonitrile. The effects of solvent polarity and hydrogen bonding on the spec...
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Solution studies were performed pH-metrically to study the interaction of Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) metal ions with 5-fluorouracil (5FU) and histamine (Hm) separately (binary) and in the presence of each other (ternary) at 25+/-0.1( degrees )C temperature and a constant ionic strength of 0.1 M NaNO(3) in aqueous solution. The ternary complexes have been found to be more stable t...
متن کاملResponse of DNA thymine synthesis in human tumor and normal tissue to 5-fluorouracil.
Thymidine-methyl-3 H and either formate-' @ C or @ C were added to incubations containing various concentrations of 5-fluorouracil. The thymine in DNA was isolated, and precursor incorporation was determined by dual-label liquid scintillation counting. MATERIALS AND METHODS The methods used in this study have been previously described (12). In summary, tissues obtained from patients who had not...
متن کاملThe effect of 5-fluorouracil on DNA-thymine synthesis in human tumors.
eluent. Uptake patterns were highly individual, and large differences were noted both in the baseline uptakes and in the effect of 5-fluorouracil on precursor incorporation. Neither tissue of origin nor control uptake influenced the in vitro response to the drug. A decrease in formate incorporation was usually associated with a reciprocal increase in thymidine incorporation. Clinical data conce...
متن کاملBase Excision by Thymine DNA Glycosylase Mediates DNA-Directed Cytotoxicity of 5-Fluorouracil
5-Fluorouracil (5-FU), a chemotherapeutic drug commonly used in cancer treatment, imbalances nucleotide pools, thereby favoring misincorporation of uracil and 5-FU into genomic DNA. The processing of these bases by DNA repair activities was proposed to cause DNA-directed cytotoxicity, but the underlying mechanisms have not been resolved. In this study, we investigated a possible role of thymine...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section C Crystal Structure Communications
سال: 2006
ISSN: 0108-2701
DOI: 10.1107/s0108270106019688